FPR Agonist 43

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FPR Agonist 43 (compound 43) 是有效的甲酰基肽受体 1 (FPR1) 和甲酰基肽受体 2 (FPR2)/ALX 双重激动剂。

FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist.

FPR Agonist 43 (10-5-107 nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells. FPR Agonist 43 is also active in the GTPγ binding assay (IC50=207±51 nM).FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells.Cell Viability Assay Cell Line:Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors Concentration:10-5, 10-3, 0.1, 10, 1000, 105, 107 nM Incubation Time:Result:Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC50 =11.6±1.9 nM).

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Others

Other Targets

Others

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903895-98-7

384.86

C20H21ClN4O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 37.5 mg/mL (97.44 mM; 超声助溶 ) H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C

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(-20℃)

With Ice Pack

≥ 2 years